Level 10 Perks
Animal Friend Requirements: Cha 6 - At first rank, animals won't attack, and at second, animals will come to your aid. The problem is that by level 10 animals will be easily killed with a single shot to the head, so all this perk really gets you is the chance to roam the wasteland without being molested by Mole Rats every two minutes.
Finesse Requirements: None - This gives you an extra chance to score a critical equal to 5 points of luck. This simply means that your chance to score a critical will increase by 5%, since every point of luck increases your chance to crit by 1%. This does continue to stack with the luck attribute even if you have the maximum of 10 luck. This perk is very useful for combat-oriented characters.
Here And Now Requirements: None - Instantly increases your level. This is good if you're impatient about leveling up, but otherwise skip it. Remember, while this may get you to the maximum level quicker, you'll have less useful perks once there.
Mister Sandman Requirements: Sneak 60 - You can instantly kill a sleeping human or ghoul while in sneak with this perk. The problem is that you almost never come across sleeping humans or ghouls, and those you do come across are usually in a public area. As a result, this perk is worthless.
Mysterious Stranger Requirements: Luck 6 - This strange perk causes a character with a powerful magnum to show up while you are in VATS. The Mysterious Stranger is very powerful and can easily one-shot most enemies. However, you'll never know when he will show up. This perk is a lot of fun, but not that useful.
Nerd Rage Requirements: Science 60, Int 5 - Basically a berserker perk for characters with a high science skill, this increases your strength to 10 and increases your damage resistance by 50% whenever your health is below 20%. Considering you rarely want to be under 20% health, and that the strength increase is capped at 10 (so if you have 10 strength already, you gain nothing) this perk is a pass.
Night Person Requirements: None - Gives you +2 to Intelligence and Perception at night up to a maximum of ten. If you don't mind always traveling at night, this is the easiest way to increase attributes in the entire game.