Built To Destroy [-]: The Built To Destroy trait affords the bonus of a +3 percent chance to Critically Hit, but your weapons will decay 15 percent faster. Only take this Trait if you’re prepared to repair your weapons a lot, or have someone do it for you. Also keep in mind that a gun that you’re using to repair another is a gun that you’re not selling for caps.
Fast Shot [-]: While using Guns and Energy Weapons you will be able to fire 20 percent more quickly but at the same time are 20 percent less accurate. If you like to get into a closer range where your aim doesn't matter quite so much then this Trait could be for you. It’s suggested that you take the Rapid Reload Perk later on however as you'll be putting yourself in positions where you'll need to reload your weapons quickly.
Four Eyes [PER < 10]: This lowers your base Perception by one point and gives you the benefit of a +2 Perception while wearing glasses. While the added Perception is always good, the lowering of your base Perception score does limit what perks you will be able to take later on, so keep this in mind when choosing this Trait.
Good Natured [-]: You immediately gain +5 percent to your Barter, Medicine, Repair, Science and Speech scores, and lose 5 percent to your Energy Weapons, Explosives, Guns, Melee Weapons, and Unarmed scores. This is a trait that you will always want to take. You will definitely use all of the non-combat skills, but will likely specialize in just one or two combat weapons. The overall tradeoff is well worth it.
Heavy Handed [-]: This Trait causes your Melee and Unarmed attacks to do more damage, but do less critical hit damage. This will allow you to have more consistent damage overall. If you’re concentrating on close combat and not counting on stealth or Luck to help you, this is definitely a trait to consider.
Kamikaze [-]: This Trait allows you to gain 10 Action Points for use in VATS, but your Damage Threshold is now lowered by 2. If you were looking to lower your Agility and raise your Endurance up for more Hit Points, this would be a viable option to help balance things out. Wearing heavier armor can certainly lessen the negatives of this Trait as well.
Loose Cannon [-]: When throwing weapons you sacrifice range for speed with this Trait, throwing weapons 30 percent faster but cutting the distance by 25 percent. If the Heave, Ho! Perk is looking tempting for you; this is a great companion to go with it.
Small Frame [AGL < 10]: Your body type becomes lighter and a little more fragile. You gain a point to your Agility, but your limbs will be damaged or crippled quicker. Not a bad Trait, but if you’re thinking of using the Adamantium Skeleton perk to lessen the effects of this trait, you should just take Intense Training instead and choose another Trait.
Trigger Discipline [-]: Both Guns and Energy Weapons will fire 20 percent more slowly, but are also 20 percent more accurate. Time is relative in VATS, and the extra accuracy will generally be a greater benefit especially if you are attacking enemies at longer range.
Wild Wasteland [-]: If the desert has you feeling too serious you can take this Trait and your adventure will be a lot more interesting. This Trait is designed to throw a lot of silly things at you, so you might want to take this on a second play through rather than your first one.