Level 8 Perks
Commando [-]: This perk increases your accuracy by 25 percent in VATS when you use any two-handed weapon. Given that two-handed weapons are generally more power than single handed weapons, this is always a great choice for a perk.
Cowboy [Guns 45, Melee 45]: Damage done by hatchets, knives, revolvers, lever-action guns and dynamite is increased by 25 percent. Great if you want to play a themed character and want to compensate for the lower damage done by these weapons compared to more modern gear.
Living Anatomy [Medicine 70]: This perk not only gives you a 5 percent damage bonus to humans and non-feral ghouls, but it also shows you both the Damage Threshold and health of your target. With this, you can always be prepared with not only the right gun for the job, but the right ammo too.
Pack Rat [INT 5, Barter 70]: When you have this perk, anything that has a weight of 2 pounds or less will have its weight cut by half. If you like to carry around a lot of different ammo types and collect bits and pieces along your way, this is a very good perk to get, especially if you’re playing in hardcore mode.
Quick Draw [AGL 5]: When you have Quick Draw, all of your weapons are equipped or put away 50 percent faster. Moving with your weapons drawn causes you to move slower, and if you use a lot of different weapons this perk makes sense. Otherwise something else would be more useful.
Rad Resistance [END 5, Survival 40]: This perk gives you a permanent 25 percent resistance to radiation. While it can be useful in hardcore mode, you could just stock up on medical supplies and get a different perk.
Scrounger [LCK 5]: When you search containers with this perk you will find more ammunition then you normally would. As ammo is worth more than caps, this perk is much better than the Fortune Finder perk. It’s also useful if you take the Hand Loader perk so you have a lot more ammo to break down.
Stonewall [STR 6, END 6]: This is a perk for your melee specialist. You gain an additional 5 Damage Threshold points and cannot be knocked down during combat. This is especially useful if you plan on going toe to toe with Deathclaws.
Strong Back [STR 5, END 5]: When you have a Strong Back you can carry a lot more with you. Especially useful in hardcore mode when you want to carry a lot of extra bits, raising the weight limit by 50 pounds can make a significant difference.
Super Slam [STR 6, Melee Weapons 45]: A very good perk for a melee fighter. Hitting an opponent with any Melee or Unarmed attack, except thrown attacks, will have a chance to knock your opponent down, enabling you to get some extra hits in while they're getting up.
Terrifying Presence [Speech 70]: Although a fun perk, its usefulness is quite limited. During select conversations you will have the option of threatening the person you're speaking to and making them run away for a few moments. As you've just told them you’re going to do very bad things to them, this turns people hostile to you after they've run for cover.