Challenge Based Perks
Abominable [3 Ranks]: At the milestones 50, 100 and 150 kills of abominations, you will do an additional 3, 6 or 10 percent extra damage to these creatures.
Animal Control [3 Ranks]: At the milestones of 50, 100 and 150 kills of mutated animals, your attacks will do an extra 3, 6 or 10 percent damage to these creatures.
Beautiful Beatdown [-]: First, kill 42 people with unarmed weapons, then do an additional 10,000 damage with unarmed weapons. Once that’s achieved Action Point costs for Unarmed attacks are reduced by 10 percent.
Bug Stomper [3 Ranks]: At the milestones of 50, 100 and 150 kills of mutated insects, your attacks will do an extra 3, 6 or 10 percent additional damage to these creatures.
Camel of the Mojave [-]: After drinking 100 water items you have become accustomed to the desert and water items will heal and hydrate you 15 percent better.
Day Tripper [-]: After using 25 addictive chems you will find their effects will last a full 33 percent longer for you.
Dine and Dash [Cannibal Perk]: After eating 25 corpses you will have the option to take your meal on the go and eat that person later.
Fast Times [-]: After using Turbo 20 times the effects of it will last 50% longer for you.
Free Radical [-]: After using RadAway 20 times, the effects of it will be improved by 20 percent.
Friendly Help [Mysterious Stranger or Miss Fortune]: After 15 visits from one of your mysterious benefactors the chance that they will appear increases. Having both does not increase your chances further though.
Lord Death [3 Ranks]: At the milestones of 200, 700 and 1000 kills of any enemy type you will do an extra 1, 2 or 4 percent additional damage to all enemies.
Machine Head [2 Ranks]: Although it’s listed at having 3 ranks, only 2 ranks are possible and later patches show only two ranks. At the milestones of 50 and 100 kills, you will do an additional 3 and 6 percent damage to robots.
Meat of Champions [Cannibal]: In order to get this perk you are required to eat four specific corpses. Mr. House, Caesar, The King and Aaron Kimball. After eating all four, eating from a corpse directly will then offer you a one minute bonus to Luck, Strength, Charisma and Intelligence
Melee Hacker [2 Ranks]: First, kill 125 enemies with melee weapons, then for the first rank you need to deal 10,000 damage with one-handed melee weapons. The second rank requires 10,000 damage with two-handed weapons. This will give an additional 5 or 10 percent bonus to your attack speed.
Mutant Massacre [3 Ranks]: At the milestones of 50, 100 and 150 kills of Super Mutants, you will add an additional 3, 6 or 10 percent damage to Super Mutants.
Power Armor Training [-]: By completing either the Still in the Dark or For Auld Lang Syne quests, you gain this perk. This will now allow you to use any Power Armor.
Set Lasers for Fun [2 Ranks]: First, kill 64 enemies with any type of energy weapons. For the first rank, inflict 25,000 damage with energy weapon rifles, and for the second rank do 16,000 damage with pistol energy weapons.
Tough Guy [-]: After becoming crippled 50 times, you will take 20 percent less damage to your limbs. If you decided to take the Small Frame trait, if you've suffered from crippled limbs for long enough this perk all but eliminates the downside of that trait.